The BLSA is a unique and invaluable resource on human aging, begun in 1958, it is a continuously enrolled cohort study of community dwelling adults that seeks to evaluate change in medical, physiological, cognitive and physical function across the adult life span. In the modern era of the study, participants are enrolled and return at regular intervals for study visits that include a wide range of testing: standard clinical assessments, specialized research instruments, laboratory tests, imaging studies, genomic panels as well as other evaluations. The study database also incorporates historical data gathered from a range of protocols over the 60-year history of the study. The BLSA encompasses a large variety of multi-dimensional data that has been managed in a siloed manner driven by topic area. Data science services are required to create a system for BLSA data processes that is cohesive, uniform, and inclusive.
PURPOSE AND OBJECTIVES:
The purpose of this requirement is to obtain methodological and technical expertise in data science in order to develop a comprehensive modern data system for the Baltimore Longitudinal Study of Aging(BLSA). This new data system will facilitate the collection, storage, integration, and maintenance of BLSA data as well as improve data documentation and access for both intramural and extramural investigators.
PROJECT REQUIREMENTS/SCOPE OF WORK:
The Contactor shall work in collaboration with BLSA investigators and study staff of the National Institute on Aging to provide data science consulting services as follows:
1. The Contractor shall evaluate all current sources and methods for data acquisition, post-processing, quality monitoring, documentation of errors and corrections as well as assembly of analytic data sets. The Contractor shall ascertain missing, redundant or deficient data system components.
a) Assess the BLSA information technology environment, including server environment, applications, devices, security, archiving and backup as well as relevant policies and procedures.
b) Assess raw data acquisition systems including the OpenClinica system, instrument data systems, and other means by which data collected on current participants enter source data sets.
c) Assess methods for and documentation of data evaluation and correction aswell as other quality control and quality improvement systems.
d) Assess data management including methods for data retrieval, aggregation,and curation.
2. The Contractor shall implement improvements or replacement of data acquisition, tracking, quality monitoring and management systems. New systems shall bedeveloped in a manner consistent with FAIR data principles standards (Findable,Accessible, Interoperable, Reusable).
a) In conjunction with BLSA investigators the Contractor shall identify and prioritize goals for BLSA data systems.
b) Specify any new information technology environment components needed to facilitate data acquisition, archiving and/or backup.
c) Design data warehousing systems including data ontologies, indexing, mappings, and curation schemas for existing source data and methods for the inclusion of future data elements. Design automated systems integrating data acquisition, post-processing, quality monitoring, management, and investigator access.
d) Formulate concurrent and longitudinal quality control processes.
e) Formulate quality improvement and dynamic data revision systems providingpost acquisition alerts and corrections.
f) Formulate accounting systems with live reporting of data warehouse components, data updating in-process, and quality control/quality improvement activities.
3. The Contractor shall incorporate historical BLSA data into new data systems as appropriate.
a) Assess the structure, format and documentation of historical data.
b) Formulate independent quality rules and quality control processes for historical data as needed.
c) Design calibration and integration systems for inclusion of historical data in the BLSA data warehouse.
4. The Contractor shall develop documentation and data access portals for investigators.
a) Assess current data access systems such as data governance and data sharing processes.
b) Design access and retrieval portals for the distribution of study source data and analytic data sets that are consistent with BLSA data governance.
c) Design integration systems for inclusion of externally processed data in the BLSA data warehouse.
5. The Contractor shall implement the new BLSA data systems through a process of testing, acceptance and transition.
a) Formulate prototype testing, acceptance and transition plans for migrating from current BLSA systems to the new system design.
b) Create a prototype buildout environment and migrate test data to the prototype build.
c) In conjunction with BLSA investigators the Contractor shall assess the prototype build based on the previously established goals for the BLSA data systems.
d) Refine any insufficient design components identified during prototype assessment and create a production BLSA data environment: data warehouse, acquisition, quality control, revision, management and access systems.
e) Transition current BLSA data systems and historical data to the production BLSA data environment.
f) Archive pre-integration datasets and documentation.
g) Support continued updates and improvements to the BLSA data system: incorporating investigator feedback and facilitating inclusion of new data elements.
ANTICIPATED PERIOD OF PERFORMANCE:
It is anticipated that a contract with a 12-month base year and three 12-month option periods will be awarded.
OTHER IMPORTANT CONSIDERATIONS:
The Government is expected to use procedures in FAR Part 12, Acquisition of Commercial Items.
CAPABILITY STATEMENT/INFORMATION SOUGHT
Respondents must provide clear and convincing documentation of their capability of providing the services specified in this notice. The respondent must also provide their DUNS number, organization name, address, point of contact, and size and type of business (e.g., 8(a), HubZone, etc., pursuant to the applicable NAICS code and any other informationthat may be helpful in developing or finalizing the acquisition requirements. Finally, respondents are also encouraged to provide a general overview of the respondent's opinions about the difficulty and/or feasibility of the potential requirement, and any other information regarding innovative ideas or concepts that may be applicable.
INFORMATION SUBMISSION INSTRUCTIONS
Respondents should provide responses accordingly: (1) submit information electronically via email. No telephone, hard copy, or facsimile responses will be accepted; (2) format capability statements using Microsoft Word or Adobe PDF including attachments, resumes, charts, etc. Use single space, 12 point font minimum and 8 1/2 x 11 page size; (3) organizematerial in such a manner that clearly identifies and addresses capability requirements and provide an executive summary; (4) capability statement should not exceed ten (10) single sided pages including references; (6) responses should be received no later than December 27, 2018 at 4:00 PM EDT; (7) include respondents' technical and administrative points of contact, Including names, titles, addresses, telephone and fax numbers, and e-mail addresses; and (8) send responses tothis notice via email to email@example.com.
Disclaimer and Important Notes: This notice does not obligate the Governmentto award a contract or otherwise pay for the information provided in response. The Government reserves the right to use information provided by respondents forany purpose deemed necessary and legally appropriate. Any organization responding to this notice should ensure that its response is complete and sufficiently detailed to allow the Government to determine the organization's qualifications to perform the work.
Respondents are advised that the Government is under no obligation to acknowledge receipt of the information received or provide feedback to respondents with respect to any information submitted. After a review of the responses received, a presolicitation synopsis and solicitation may be published in Federal Business Opportunities. However, responses to this notice will not be considered adequate responses to a solicitation.
Confidentiality: No proprietary, classified, confidential, or sensitive information should be included in your response. The Government reserves the right to use any non-proprietary technical information in any resultant solicitation(s).
CITE: https://www.fbo.gov/spg/HHS/NIH/NIDA-01/ HHS-NIH-NIDA(AG)-SBSS-75N95019R00020/listing.html